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Altered production and proteolytic processing of brevican by transforming growth factor β in cultured astrocytes

✍ Scribed by Michelle G. Hamel; Joanne Mayer; Paul E. Gottschall

Book ID
111178916
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
286 KB
Volume
93
Category
Article
ISSN
0022-3042

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## Abstract Reactive astrocytes surround amyloid depositions and degenerating neurons in Alzheimer's disease (AD). It has been previously shown that β‐amyloid peptide induces inflammatory‐like responses in astrocytes, leading to neuronal pathology. Reactive astrocytes up‐regulate nerve growth facto