Altered Peptide Ligands Induce Delayed CD8-T Cell Receptor Interaction—a Role for CD8 in Distinguishing Antigen Quality

A subpopulation of CD8+ T cells specific

A subpopulation of CD8+ T cells specific for melanocyte differentiation antigens expresses killer inhibitory receptors (KIR) in healthy donors: evidence for a role of KIR in the control of peripheral tolerance

✍ Bertrand Huard; Lars Karlsson 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 165 KB 👁 2 views

In cancer patients, NK cell inhibitory receptors (IR) are expressed on a fraction of melanomaspecific lymphocytes with a unique reactivity for tumor antigens derived from normal, nonmutated genes (differentiation antigens). It is presently not known whether expression of these receptors is induced d