Altered metabolism of serotonin in the brain of the rat after chronic ingestion ofd-amphetamine

✍ Scribed by José-Luis Díaz; Matti O. Huttunen

• Publisher: Springer
• Year: 1972
• Tongue: English
• Weight: 488 KB
• Volume: 23
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00406739

✦ Synopsis

Dextro-amphetamine at doses of 1 mg/kg/day was administered intragastrically to rats for one month. At 18 h after the final dose, a small (16~ increase of brain serotonin concentration was found as well as an increase (300/0) of the synthesis and degradation of [SH] serotonin formed from intracisternally injected exogenous [aH]-L-tryptophan.