Altered interleukin-2 secretion in patients with primary fibromyalgia syndrome

✍ Scribed by Nader Hader; David Rimon; Amalia Kinarty; Nitza Lahat

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 612 KB
• Volume: 34
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780340712

✦ Synopsis

Interleukin-2 (IL-2) production was studied in T lymphocytes and isolated CD4+ T lymphocytes from 12 patients with primary fibromyalgia syndrome and 10 healthy volunteers. The dose and time kinetics of IL-2 production by concanavalin A-stimulated T cells and CD4+ T cells of fibromyalgia patients differed from findings in controls by 1) a need for a higher concentration of mitogen in order to achieve optimal IL-2 secretion, and 2) a delay in the peak time of optimal IL-2 secretion. Unlike normal IL-2 secretion, which was higher after removal of CDS+ T cells, the pattern and degree of IL-2 secretion by cells from fibromyalgia patients were not changed following removal of CDS+ T cells. Addition of calcium ionophore in assays using suboptimal concanavalin A concentrations did not correct the reduction in IL-2 secretion by fibromyalgia patient T cells, but addition of phorbol myristate acetate induced normal secretion of IL-2. These findings suggest that there is a defect in the IL-2 pathway, which is related to protein kinase C activation and does not involve impairment of CaZ+ elevation, in patients with fibrom yalgia .

Primary fibromyalgia syndrome is a commonly diagnosed rheumatic disease (l), but its etiology remains