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Altered innate immune response of plasmacytoid dendritic cells in multiple sclerosis

✍ Scribed by A. Bayas; M. Stasiolek; N. Kruse; K. V. Toyka; K. Selmaj; R. Gold

Book ID: 108701059
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 319 KB
Volume: 157
Category: Article
ISSN: 0009-9104
DOI: 10.1111/j.1365-2249.2009.03964.x

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## Background: The G protein alpha subunit type-2 (G␣ i 2)-deficient mouse develops inflammatory bowel disease (IBD) with increased severity in mice on a 129SvEv (129) background compared to the C57BL/6 (B6) background. Since dendritic cells (DCs) are key cells of innate immunity, we determined wh