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Altered glucose transport kinetics in murine sarcoma virus-transformed BALB/3T3 clones

✍ Scribed by Masakazu Hatanaka; George J. Todaro; Raymond V. Gilden

Book ID
102275916
Publisher
John Wiley and Sons
Year
1970
Tongue
French
Weight
384 KB
Volume
5
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The kinetics of glucose transport were determined for a number of spontaneous and virus‐transformed cell lines derived from a single clone of BALB/3T3 cells. SV40‐transformed and mouse leukemia virus‐infected cells were characterized by a Km very similar to that of the parental cell line. In contrast, murine sarcoma virus‐transformed cells had a much lower Km. These findings are in agreement with previous results obtained with mass cultures of NIH Swiss mouse embryo cells. One X‐irradiation and two spontaneous transformants also showed low Km values and no virions or virion antigens. These latter cell lines should provide an opportunity for a crucial test of the relationship between glucose transport kinetics and a functional sarcoma virus genome.

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Differences in cytochalasin B inhibition
Differences in cytochalasin B inhibition of 3-O-methylglucose uptake between BALB/3T3 cells and a murine sarcoma virus transformed clone
✍ Jon C. Graff; David J. Hanson; Masakazu Hatanaka 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 French ⚖ 690 KB

## Abstract Cytochalasin B, a mold metabolite, in concentrations of 10 μg per ml, showed a different inhibitory effect on the uptake of 3‐O‐methylglucose between a cell line transformed by the Kirsten strain of murine sarcoma virus, and its non‐transformed parent line. When the overall uptake of 3‐