Gain-of-function mutations in Notch-1 are common in T-cell lymphoblastic leukemia (T-ALL), making this receptor a promising target for drugs such as gamma-secretase inhibitors (GSIs). However, GSIs seem to be active in only a small fraction of T-ALL cell lines with constitutive Notch-1 activity and
โฆ LIBER โฆ
Altered expression of the cell cycle regulatory protein cyclin D1 in the rat dentate gyrus after adrenalectomy-induced granular cell loss
โ Scribed by J.Antonio Postigo; Ysbrand D Van der Werf; Jakob Korf; Harm J Krugers
- Book ID
- 117476054
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 357 KB
- Volume
- 241
- Category
- Article
- ISSN
- 0304-3940
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Notch-1 regulates Akt signaling pathway
โ
Dongmei Guo; Jingjing Ye; Jianjian Dai; Lizhen Li; Feng Chen; Daoxin Ma; Chunyan
๐
Article
๐
2009
๐
Elsevier Science
๐
English
โ 937 KB
Alterations in the expression of the cel
โ
Ma'anit Shapira; Ofer Ben-Izhak; Bishara Bishara; Boris Futerman; Ira Minkov; Mi
๐
Article
๐
2004
๐
John Wiley and Sons
๐
English
โ 250 KB
๐ 2 views
## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio
Expression of the cell-cycle regulatory
โ
Andrzej Semczuk; Roman Miturski; Danuta Skomra; Jerzy A. Jakowicki
๐
Article
๐
2004
๐
Springer
๐
English
โ 307 KB