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Altered Expression and Regulation of the α5β1 Integrin–Fibronectin Receptor Lead to Reduced Amounts of Functional α5β1 Heterodimer on the Plasma Membrane of Senescent Human Diploid Fibroblasts

✍ Scribed by Qubai Hu; Elena J. Moerman; Samuel Goldstein

Book ID
115602358
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
336 KB
Volume
224
Category
Article
ISSN
0014-4827

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Cytofluorimetric and reverse-transcription polymerase chain reaction (RT-PCR) analysis showed that adriamycinresistant (ADR R ), but not sensitive (WT), MCF-7 human mammary carcinoma cell lines express a4b1 and a5b1 integrins. ADR R cells adhere to fibronectin (FN), and only a5b1 is involved in cell