Comparative study on altered hepatic met
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Jun-ichi Kusaba; Noriko Kajikawa; Hiromu Kawasaki; Yuji Kurosaki; Tetsuya Aiba
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Article
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2012
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John Wiley and Sons
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English
โ 147 KB
๐ 1 views
To examine the mechanism accounting for the diverse alteration of hepatic metabolism of CYP3A substrates observed with renal function being severely impaired, the hepatic drug metabolizing activity was evaluated using liver microsomes prepared from rats with glycerol-induced acute renal failure (ARF