Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
✍ Scribed by Dalemans, Wilfried; Barbry, Pascal; Champigny, Guy; Jallat, Sophie; Jallat, Sophie; Dott, Karin; Dreyer, Dominique; Crystal, Ronald G.; Pavirani, Andréa; Lecocq, Jean-Pierre
- Book ID
- 109779159
- Publisher
- Nature Publishing Group
- Year
- 1991
- Tongue
- English
- Weight
- 467 KB
- Volume
- 354
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/354526a0
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Cystic fibrosis (CF) is the most common autosomal recessive disease in the Caucasian population. The disease can be caused by one of the more than 900 different mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene. However, the deletion of the phe508-codon is the most pre
The majority of the identified cystic fibrosis (CF) mutations are very uncommon in the total patient population, making the correlation between the clinical presentation and the molecular alterations difficult. The largest deletion that has been described so far in C F is of 84 bp in exon 13, which