Altered binding of regulatory factors to HLA class I enhancer sequence in tumor cell lines lacking class I antigen expression
β Scribed by Sussman, Elliot J.; Strom, Brain L.; Soper, Keith
- Book ID
- 122477605
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 67 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0198-8859
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Tumor cells frequently show a lack of surface class-I major histocompatibility complex (MHC) antigen expression. These molecules are key recognition structures for immune rejection of tumor cells and their absence at the surface of tumor cells could favor the progression of tumors. We have analyzed
HLA class I molecules present antigenic peptides to cytotoxic T lymphocytes and thus play an important role in immune surveillance of cells infected with virus or altered by malignant transformation. Immunochemical studies have demonstrated a marked deficiency or lack of expression of class I molecu