Altered antigenicities of hepatitis B virus surface antigen carrying mutations outside the common “a” determinant
✍ Scribed by Wei Ning Chen; Chong Jin Oon; Ivy Toh
- Book ID
- 119388793
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 34 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0002-9270
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Antibody to the common "a" determinant of hepatitis B surface antigen (HBsAg) protects against infection with hepatitis B virus. A number of variant surface antigens with amino acid substitutions within the "a" determinant have been described in patients around the world. Both wild type and variant
Fusion of peptide epitopes to the core antigen (HBcAg) of hepatitis B virus (HBV) enhances their immunogenicity, both quantitatively and qualitatively. In a number of vaccine-induced mutants of HBV, glycine145 of the surface antigen S polypeptide (HBsAg) has been replaced by arginine, resulting in l