The basis for the markedly altered intracellular binding of ['Hlvincristine in a multidrug-resistant variant (DC-3FNCRd-SL) of Chinese hamster lung cells [DC-3F) was investigated. Binding of [3Hlvincristine by protein in cytosol derived from each cell type exhibited a differing requirement for GTP i
โฆ LIBER โฆ
Altered aconitase activity in hamster cells selected for resistance to fluorocitrate
โ Scribed by Jim A. Wright
- Book ID
- 118310179
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- English
- Weight
- 404 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0006-291X
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## Abstract From the Chinese hamster ovary (CHO) cell, genetic variants (Mon^R^โ31 and Mon^R^โ32) relatively resistant to monensin, an ionophoric antibiotic, have been isolated. Growth of both Mon^R^โ31 and Mon^R^โ32 clones required higher doses of serum than CHO. Addition of insulin to media conta