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Alterations of the ubiquitin–proteasome system in cardiomyopathic cMyBP-C mice

✍ Scribed by K.R. Sultan; S. Schlossarek; D. Englmann; N. Vignier; T. Eschenhagen; L. Carrier


Book ID
116984903
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
47 KB
Volume
42
Category
Article
ISSN
0022-2828

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Ubiquitin-proteasome system alterations
✍ Jesse M. Hunter; Mathieu Lesort; Gail V.W. Johnson 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 505 KB

## Abstract Huntington's disease (HD) is a progressive, autosomal dominant neurodegenerative disease caused by an abnormally expanded CAG repeat in the HD gene. Ubiquitylated aggregates containing mutant huntingtin protein in neurons are hallmarks of HD. Misfolded mutant huntingtin monomers, oligom