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Alterations of the Medullary Epithelial Compartment in the Aire-Deficient Thymus: Implications for Programs of Thymic Epithelial Differentiation

✍ Scribed by Dooley, J.; Erickson, M.; Farr, A. G.

Book ID
124168824
Publisher
American Association of Immunologists
Year
2008
Tongue
English
Weight
684 KB
Volume
181
Category
Article
ISSN
0022-1767

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## Abstract The current prevailing view regarding the role of Aire in self‐tolerance is that it is involved in the transcriptional control of many tissue‐restricted self‐antigen genes in thymic epithelial cells in the medulla (mTECs); however, accumulating evidence also suggests that Aire has other