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Alterations of repeated sequences in 5′ upstream and coding regions in colorectal tumors from patients with hereditary nonpolyposis colorectal cancer and Turcot syndrome

✍ Scribed by Miyaki, Michiko; Iijima, Takeru; Shiba, Kiyotaka; Aki, Toshihiko; Kita, Yumi; Yasuno, Masamichi; Mori, Takeo; Kuroki, Toshio; Iwama, Takeo

Book ID
110064841
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
143 KB
Volume
20
Category
Article
ISSN
0950-9232

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## BACKGROUND. The hereditary nonpolyposis colorectal carcinoma (HNPCC) syndrome is an autosomal dominant genetic disorder caused by the inheritance of a mutation in one of a family of genes encoding DNA mismatch repair (MMR) proteins. HNPCC manifests as genetic instability in linked tumors. Clini