## Abstract The genes __CDKN2B (MTS2__) and __CDKN2 (MTSI)__ encoding the proteins p15 and p16 are both located on chromosomal band 9p21, a locus at which frequent homozygous and heterozygous deletions occur in many primary human tumors, including esophageal carcinoma. __CDKN2__ and __CDKN2B__ belo
Alterations of CDKN2A, p53 and related cell cycle regulatory genes in esophageal squamous cell carcinoma
โ Scribed by J. Smeds; P. Berggren; X. Ma; Z. Xu; R. Kumar; K. Hemminki
- Book ID
- 117657942
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 166 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0959-8049
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๐ SIMILAR VOLUMES
## Abstract Because previous studies have shown that loss of heterozygosity (LOH) is common on chromosome arm 9p in esophageal squamous cell carcinoma (ESCC) and that genetic alterations in __CDKN2A__ and __CDKN2B__ on 9p are also common, we sought to determine whether LOH and these genetic alterat
To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.