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Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver

✍ Scribed by E.K. Choi; S. Uyeno; N. Nishida; T. Okumoto; S. Fujimura; Y. Aoki; M. Nata; K. Sagisaka; Y. Fukuda; K. Nakao; T. Yoshimoto; Y.S. Kim; T. Ono

Book ID
113194956
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
556 KB
Volume
354
Category
Article
ISSN
0027-5107

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The Hindlll c-sis RFLP was analyzed in constitutional and tumor DNAs of 19 meningiorna patients. Loss of a c-sis allele (allele I in all cases) was observed in 6 out of 10 tumors from heterozygous patients. No alteration in the structure or dosage of the c-sis gene was detected in any tumor sample.