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Alterations in the size of the poly(a) segment in newly-synthesized messenger RNA of mouse sarcoma 180 ascites cells

โœ Scribed by George Brawerman

Publisher
Springer
Year
1973
Tongue
English
Weight
408 KB
Volume
1
Category
Article
ISSN
0301-4851

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โœฆ Synopsis

The size of the poly(A) segment present at the 3'-end of mRNA molecules decreases gradually after entry of the mRNA into the cytoplasm. The size reduction seems to occur equally in free and polysome-bound mRNA. It is not affected by conditions that inhibit protein synthesis, such as treatment with cycloheximide and amino acid deprivation. The latter condition leads to a substantial increase in the size of nuclear poly(A). The rate of poly(A) cleavage could determine the length of time a mRNA molecule remains functional in the cytoplasm.

๐Ÿ“œ SIMILAR VOLUMES

Size of the poly(A) region in mouse glob
Size of the poly(A) region in mouse globin messenger RNA
โœ Marcelle R. Morrison; Christian G. Merkel; Jerry B. Lingrel ๐Ÿ“‚ Article ๐Ÿ“… 1973 ๐Ÿ› Springer ๐ŸŒ English โš– 350 KB

A 9S RNA fraction from mouse reticulocytes, containing the active ฮฑ- and ฮฒ-globin mRNAs, has been isolated by hybridization of the polyadenylate regions in the mRNAs to oligo(dT)-cellulose. The adenylate-rich sequence isolated by limited RNase digestion of the globin mRNAs migrates between 4S and 5S