Alterations in the signal-transducing molecules of T cells and nk cells in colorectal tumor-infiltrating, gut mucosal and peripheral lymphocytes: Correlation with the stage of the disease
✍ Scribed by Masanori Matsuda; Max Petersson; Rodica Lenkei; Jean-Luc Taupin; Inger Magnusson; Håkan Mellstedt; Paul Anderson; Rolf Kiessling
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- French
- Weight
- 997 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
T cells from mice bearing an experimental colon carcinoma, and from patients with colorectal and renal carcinomas, have atypical T-cell receptors (TCR). In the present study, further characterization of modulations in CD3-and CD 16-associated t; chain in peripheral blood lymphocytes (PBL) and tumorinfiltrating lymphocytes (TlL) from colorectal carcinomas was performed. Relative to PBL, the percentage of natural killer (NK) cells among fresh TIL was reduced, while a higher proportion of T cells expressing HLA-DR was found. As previously reported, we found significantly reduced levels of the CD3-and CD 16-associated t; chain in TIL and, to a lesser extent, also in patients' PBL. Levels oft; chain in T and NK cells from non-cancerous colorectal tissue from patients were lower than in PBL but higher than in TIL, with a direct relationship between levels of this signal-transducing molecule and the distance from the tumor. In addition, 1; levels correlated with the Dukes' stage of the disease, since PBL from patients with lymph-node involvement or distant organ metastases (Dukes'