Alterations in the levels of stem cells (CFU-s) and plaque-forming cells (PFC) in mice during chronic phenylhydrazine-lnduced hemolytic anemia
✍ Scribed by Kozlov, V. A. ;Zhuravkin, I. N. ;Coleman, R. M. ;Rencricca, N. J.
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 334 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
Abstract
The levels of splenic and medullary pluripotent stem cells (CFU‐s) and splenic plaque‐forming cells (PFC) to sheep red blood cells (SRBC) were monitored in mice during the course of mild chronic phenylhydrazine (PHZ)‐induced hemolytic anemia. The levels of CFU‐s were significantly depressed in the bone marrow and elevated in the spleen throughout. These changes are most likely due to increased CFU‐s migration from marrow to spleen. In this regard, migration of CFU‐s from limb‐shielded marrow to thespleen of irradiated PHZ‐treated mice was demonstrated. Lastly, the numbers of splenic PFC to SRBC were significantly and constantly depressed throughout the course of hemolytic anemia and enhanced erythropoiesis. Stem cell competition between erythroidand lymphoid lines of differentiation may have contributed to the observed reduced immune response.