Alterations in the expression of P2X1 receptors in failing and nondiseased human atria

✍ Scribed by Desiree Berry; Mu Yao; Julian A. Barden; Vladimir J. Balcar; Mitchell A. Hansen; Maxwell R. Bennett; Anne Keogh; Dr. Cristobal G. dos Remedios

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 487 KB
• Volume: 19
• Category: Article
• ISSN: 0173-0835
• DOI: 10.1002/elps.1150190542

✦ Synopsis

Alterations in the expression of P,,, receptors in failing and nondiseased human atria

This is the first report of the analysis of the ATP-specific P,,, receptor subunit in human hearts. We have examined homogenate samples of human left atria for the presence of P,,, receptors using Western blots. Anti-P,,, immunoreactivity was detected in populations of nondiseased atria as well as in atria from explanted hearts from patients with terminally failing heart conditions such as dilated cardiomyopathy. At least three groups of P,,, immunoreactive proteins were detected in the Western blots with approximate molecular mass values of 50, 70, and 160 kDa. We report changes in expression of their 50 and 70 kDa components. These changes may be related to the type of deficit in these hearts since the changes have been observed in hearts with decreased ejection fractions characteristic of dilated cardiomyopathy.