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Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis

โœ Scribed by Shoichi Sasaki; Takahiro Takeda; Noriyuki Shibata; Makio Kobayashi


Book ID
116772266
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
1004 KB
Volume
478
Category
Article
ISSN
0304-3940

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## Abstract In amyotrophic lateral sclerosis (ALS), neuronal loss and axonal degeneration occur in motor neurons. Although there is limited axonal regeneration, surviving motor neurons send collateral sprouts to denervated muscle fibers. GAPโ€43, a protein enriched in growth cones and synaptic termi