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Alterations in enzyme activity in tumors and the implications for chemotherapy

✍ Scribed by G.A. LePage

Book ID
118371706
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
484 KB
Volume
8
Category
Article
ISSN
0065-2571

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Specific genetic alterations affecting known tumor suppressor genes and proto-oncogenes occur during mouse lung tumorigenesis. These include mutational activation of the K-ras gene, commonly seen at a frequency of about 80% in both spontaneously occurring and chemically induced adenomas and adenocar