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Alterations in energy status by menadione metabolism in hepatocytes isolated from fasted and fed rats

✍ Scribed by Frank A.M. Redegeld; Ralf M.W. Moison; Andries Sj. Koster; Jan Noordhoek

Book ID
115708070
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
716 KB
Volume
273
Category
Article
ISSN
0003-9861

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Alterations in intracellular thiol homeo
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✍ Donato Di Monte; David Ross; Giorgio Bellomo; Lena EklΓΆw; Sten Orrenius πŸ“‚ Article πŸ“… 1984 πŸ› Elsevier Science 🌐 English βš– 822 KB

The effects of menadione (2-methyl-1,4-naphthoquinone) metabolism on intracellular soluble and protein-bound thiols were investigated in freshly isolated rat hepatocytes. Menadione was found to cause a dose-dependent decrease in intracellular glutathione (GSH) level by three different mechanisms: (a