Alterations in DNA methylation in human colon neoplasia
โ Scribed by Andrew P. Feinberg; Bert Vogelstein
- Book ID
- 118286425
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 431 KB
- Volume
- 3
- Category
- Article
- ISSN
- 8756-0437
No coin nor oath required. For personal study only.
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We report that CpG island methylation, an epigenetic modification of DNA known to correlate closely with silencing of gene transcription, appears in the oestrogen receptor (ER) gene in a subpopulation of cells which increases as a direct function of age in human colonic mucosa. This same methylation
Considerable alteration of cellular carbohydrates such as glycolipids and glycoproteins occurs in colonic neoplasia. Some of these changes are also observed at certain embryonic stages of differentiation and are, therefore, considered onco-developmental changes. In colon cancer cells, many of the ph