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Alterations in components of the TGF-β superfamily signaling pathways in human cancer

✍ Scribed by Laurence Levy; Caroline S. Hill


Book ID
116401004
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
397 KB
Volume
17
Category
Article
ISSN
1359-6101

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Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different serine/threonine kinase receptors, i.e. type I and type II receptors. Upon ligand binding, type I receptors specifically activate intracellular Smad proteins. R‐Smads are direct substrates of type I receptors; Smad