Alterations in Adrenergic Receptor Signaling in Heart Failure
β Scribed by Sumant Lamba; William T. Abraham
- Book ID
- 110282448
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 133 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1382-4147
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π SIMILAR VOLUMES
Moderate and severe stages of congestive heart failure due to the loss of myocardium upon coronary occlusion in rats was associated with an increase in alpha-adrenergic receptors and a decrease in beta-adrenergic receptors in the viable left ventricle. However, at early stages of heart failure the n
In end-stage heart failure the expression of different myocardial regulatory proteins involved in the beta-adrenergic cAMP signalling pathway is altered. The downregulation of beta 1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding