Gsα activity is reduced in erythrocyte m
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Celia Zazo; Susanne Thiele; Cesar Martín; Eduardo Fernandez-Rebollo; Lorea Marti
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Article
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2011
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American Society for Bone and Mineral Research
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English
⚖ 163 KB
## Abstract In pseudohypoparathyroidism (PHP), PTH resistance results from impairment of signal transduction of G protein–coupled receptors caused by a deficiency of the Gsα‐cAMP signaling cascade due to diminished Gsα activity in maternally imprinted tissues. In PHP‐Ia, inactivating mutations of t