𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Alteration of the behavioral effects of amphetamine by agents which modify cholinergic function

✍ Scribed by M. E. Goldberg; V. B. Ciofalo

Publisher
Springer
Year
1969
Tongue
English
Weight
482 KB
Volume
14
Category
Article
ISSN
0033-3158

No coin nor oath required. For personal study only.

✦ Synopsis

Amphetamine was administered to a group of rats trained on a nondiseriminated avoidance procedure. An intraperitoneal dose of 2.0 mg/kg caused about a 75% increase in response rate for the three-hour session. Doses of atropine, Tremorine, eserine, and 4-(1-naphthylvinyl)-pyridine (NVP), an inhibitor of the enzyme choline acetylase, which were ineffective in themselves, markedly affected the increase in rate observed after amphetamine. The quarternary amine of NVP was without effect on the amphetamine response. Those agents that decreased cholinergie function, either by blocking the effect of acetylcholine or by preventing its synthesis, augmented the stimulating effect of amphetamine. Cholinergic stimulants, on the other hand, significantly antagonized the behavioral effects of amphetamine.

πŸ“œ SIMILAR VOLUMES

Antagonism of the behavioral effects of
Antagonism of the behavioral effects of cocaine andd-amphetamine by prazosin
✍ Richard E. Tessel; James E. Barrett πŸ“‚ Article πŸ“… 1986 πŸ› Springer 🌐 English βš– 551 KB

Key pecking by pigeons was maintained under a 30-response fixed-ratio schedule of food delivery; lever pressing by squirrel monkeys was maintained under a 3-min fixed-interval schedule of food delivery. Administered alone, d-amphetamine (0.1-3.0 mg/kg), cocaine (1.0-3.0 mg/kg) and bupropion (1.0-30

Alteration of the disruptive effect of f
Alteration of the disruptive effect of fenfluramine on food consumption in the rat by repeated post-session administration ofd-amphetamine
✍ Ronald N. Hunsinger; T. Bradford Barnes; John C. Kapeghian; Marvin C. Wilson πŸ“‚ Article πŸ“… 1981 πŸ› Springer 🌐 English βš– 583 KB

The purpose of this study was to determine whether repeated treatment (15 days) with d-amphetamine (AMP) or fenfluramine (FEN), administered after a daily 3 h feeding session (e. g. post-session), would result in tolerance or crosstolerance to the decrement in food consumption induced by treatment w