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Alteration of p16 (CDKN2) gene is associated with interleukin-2–induced tumor cell growth in adult T-cell leukemia

✍ Scribed by Hiroshi Fujiwara; Naomichi Arima; Tomoko Hashimoto-Tamaoki; Kakushi Matsushita; Hideo Ohtsubo; Kosei Arimura; Shiroh Hidaka; Chuwa Tei

Book ID: 114217360
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 227 KB
Volume: 27
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(99)00035-1

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The G 1 /S checkpoint of the cell cycle is regulated by p16, p53 and RB tumor suppressor genes. Loss of expression of the p16 INK4 tumor suppressor protein, the product of the CDKN2 gene, has been associated with a wide variety of human malignancies. Mutations, loss of heterozygosity and deletions o