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Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation

✍ Scribed by Miki Hara-Yokoyama; Tomoko Kimura; Hiroaki Kaku; Motoaki Wakiyama; Yoko Kaitsu; Mio Inoue; Seisuke Kusano; Mikako Shirouzu; Shigeyuki Yokoyama; Toshiaki Katada; Yoshio Hirabayashi; Kiyoshi Takatsu; Masaki Yanagishita

Book ID: 116576274
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 883 KB
Volume: 8
Category: Article
ISSN: 1567-5769
DOI: 10.1016/j.intimp.2007.10.010

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## Anti -CD3 ؋ anti-B-cell antigen bispecific monoclonal antibodies (bsAbs) can redirect T-cell-mediated lysis toward malignant B cells. Clinical trials with CD3-based bsAbs have shown toxicity in patients which is likely related to nonspecific T-cell activation and targeting. Our current studies