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Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wild-type p53 gene in human lung cancer cells

✍ Scribed by Osaki, Shin-ichi; Nakanishi, Yoichi; Takayama, Koichi; Pei, Xin-Hai; Ueno, Hikaru; Hara, Nobuyuki


Book ID
110017650
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
278 KB
Volume
7
Category
Article
ISSN
0929-1903

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HCC patients are generally resistant to chemotherapy, Selective expression of cytotoxic gene products in tuwhich, in some cases, may be the result of a loss of function mor cells is one of the goals of gene therapy for treating mutation in the p53 gene. cancer. We are developing such a strategy for