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Alteration in the expression of cdk4 and cdk6 proteins in oral cancer and premalignant lesions

โœ Scribed by Sopee Poomsawat; Waranun Buajeeb; Siribang-on Khovidhunkit; Jirapa Punyasingh


Book ID
111255375
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
648 KB
Volume
39
Category
Article
ISSN
0904-2512

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Altered expression of cyclin D1 and CDK4
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We analyzed the expression and amplification of cyclin D1 and CDK4 genes in ovarian carcinomas. Northern blot analysis revealed overexpression of cyclin D1 in 12 of 65 (18%) ovarian carcinomas while CDK4 was overexpressed in 7 of 48 cases (14%). None of the tumors showed amplification of any of the