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Alteration in RNA synthesis in the dorsal root ganglia of methylmercury-treated rats

✍ Scribed by Satoshi Nagumo; Saburo Omata; Hiroshi Sugano

Publisher: Springer-Verlag
Year: 1985
Tongue: English
Weight: 545 KB
Volume: 56
Category: Article
ISSN: 0340-5761
DOI: 10.1007/bf00295160

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✦ Synopsis

The effect of methylmercury in vivo on the incorporation of 3H-uridine in vitro into RNA of dorsal root ganglia of the rat was examined. Modified methods for the incubation of the tissue and extraction of RNA were applied to adequately determine the rate of RNA synthesis. Methylmercury significantly decreased the RNA content and RNA synthetic activity only in the symptomatic period, while uptake of the precursor into the acid-soluble pool remained unchanged. These results indicate that the previously reported inhibition of protein synthesis in dorsal root ganglia at an early phase of methylmercury intoxication was not due to impairment RNA synthesis in this tissue.

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