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Alteration in Ion Channel Function of Mouse Nicotinic Acetylcholine Receptor by Mutations in the M4 Transmembrane Domain

✍ Scribed by S. Tamamizu; Y.-H. Lee; B. Hung; M.G. McNamee; J.A. Lasalde-Dominicci


Publisher
Springer
Year
1999
Tongue
English
Weight
367 KB
Volume
170
Category
Article
ISSN
0022-2631

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## Abstract The αM4 transmembrane domain of the nicotinic acetylcholine receptor (AChR) is flanked by two basic amino acids (His^408^ and Arg^429^) located at its cytoplasmic‐ and extracellular‐facing extremes, respectively, at the level of the phospholipid polar head regions of the postsynaptic me