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ALS Drug Development: Reflections from the Past and a Way Forward

✍ Scribed by Swati Aggarwal; Merit Cudkowicz

Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
246 KB
Volume
5
Category
Article
ISSN
1933-7213

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✦ Synopsis

Tremendous advances in our understanding of pathogenesis of amyotrophic lateral sclerosis (ALS) have provided a rich pipeline of drugs for clinical trialists. At least 32 unique compounds have been tested. Nevertheless, riluzole is currently the only treatment that prolongs survival. We present a critical overview of past clinical trials, how therapies are selected for testing in people, challenges with ALS clinical trial design and conduct, and ways to best move forward.

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