Alphaviruses as expression vectors
β Scribed by Kenneth Lundstrom
- Book ID
- 104361993
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 654 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
β¦ Synopsis
Alphavirus vectors have been used for efficient high-level expression of a variety of topologically different proteins, allowing studies of protein transport, localization and functional activity in a broad range of host cells. Complex transmembrane proteins have been produced in large quantities through the establishment of scale-up technology.
Alphavirus vectors have also shown promising potential in vaccine production and preliminary gene therapy applications.
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Recent advances in baculovirus expression vector technology include improvements to methods for the selection of recombinant viruses and further developments in virion display vectors. It is now also possible to modify the host cell glycosylation pathway to alter the structure of glycans added to th