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Alpha1-antitrypsin deficiency associated with PZ and MP phenotypes: Clinical and laboratory correlations

โœ Scribed by Irving P. Crawford; Arthur Dawson; Donald D. Stevenson


Book ID
115676156
Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
870 KB
Volume
57
Category
Article
ISSN
1555-7162

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Chronic liver disease affects up to 20% of children with alpha 1-antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesi