Alpha1-adrenoceptors (α1-AR) and vascular smooth muscle cell growth

✍ Scribed by Brian B. Hoffman; Zhuo-Wei Hu

• Book ID: 101321039
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 231 KB
• Volume: 45
• Category: Article
• ISSN: 0270-4137
• DOI: 10.1002/1097-0045(2000)45:9+<29::aid-pros7>3.0.co;2-z

✦ Synopsis

BACKGROUND. Smooth muscle cells in vascular tissue, like tissue within the urogenital sinus, undergo growth and proliferation. METHODS. This review attempts to compare and contrast the mechanisms and controlling factors involved in prostatic and vascular tissue. There is a particular focus on the role of catecholamines and alpha-adrenoceptors (␣-ARs), and on the effects of ␣ 1 -AR antagonists (blockers) on cellular dynamics. RESULTS AND CONCLUSIONS. The situation in vascular tissue appears analagous to that in prostatic tissue. Certain AR-antagonists, in addition to altering smooth muscle contraction, may have other actions on cellular dynamics.