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.alpha.-Fluorination of ketones. 1. Direct fluorination of pyruvic acid derivatives by using molecular fluorine

✍ Scribed by Tsushima, Tadahiko; Kawada, Kenji; Tsuji, Teruji; Misaki, Susumu


Book ID
125835246
Publisher
American Chemical Society
Year
1982
Tongue
English
Weight
565 KB
Volume
47
Category
Article
ISSN
0022-3263

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## Abstract A facile procedure for preparing 4‐fluoroantipyrine is reported. Treatment of antipyrine with molecular fluorine gives 4‐fluoroantipyrine (3) and 4,4‐difluoro‐3‐hydroxy‐2,3‐dimethyl‐1‐phenylpyrazolidin‐5‐one (2). The product distribution depends on the ratio of antipyrine and molecular