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Alpha-1-antitrypsin phenotypes in a group of newborn infants in Somalia

✍ Scribed by Guido Massi; Fabio M. Vecchio

Publisher
Springer
Year
1977
Tongue
English
Weight
242 KB
Volume
38
Category
Article
ISSN
0340-6717

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✦ Synopsis

Pi phenotype determinations were performed on umbilical cord serum specimens of 347 infants born in Mogadishu (Somalia) hospitals. Phenotyping was performed by isoelectric focusing on polyacrylamide gel slabs. Sera containing a~AT in types other than MM were also studied by crossed antigen-antibody immunoelectrophoresis on agar.

The most frequently occuring Pi allele proved to be PiM. With respect to the other African populations studied so far, there was a high prevalence of the PiS and PiZ alleles. In particular, three individuals were found with the ZZ phenotype, which had not yet been observed in Africa.

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