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Alpha-1-Antitrypsin Deficiency: Current Concepts

โœ Scribed by Alan T. Mulgrew; Clifford C. Taggart; N. Gerry McElvaney


Publisher
Springer
Year
2007
Tongue
English
Weight
293 KB
Volume
185
Category
Article
ISSN
0341-2040

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๐Ÿ“œ SIMILAR VOLUMES


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The results of a neonatal screening programme for alpha-1-antitrypsin deficiency are presented. Cord blood samples with an alpha-1-antitrypsin concentration below 1.628 mg/ml, as measured by an enzyme-linked immunosorbent assay method, were phenotyped by isoelectric focusing in polyacrylamide gels.

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## Liver injury in PiZZ cY,-antitrypsin &-AT) deficiency probably results from toxic effects of the abnormal a,- AT molecule accumulating within the ER of liver cells.