✦ LIBER ✦
Allylsilane addition on C-13 of 11-methoxycarbonyl-17-acetyl-1,3,5(10),13(17)-gonatetraenes: a straightforward route to introduce an 18α-methyl group
✍ Scribed by Pierre-Yves Michellys; Philippe Maurin; Hélène Pellissier; Maurice Santelli
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 112 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
The conjugate addition of allylsilane (Sakurai reaction) to 11-methoxycarbonyl-17-acetyl-1,3,5(10),13(17)-gonatetraenes provided 13a-allyl steroids. Ozonolysis followed by a decarbonylation affords steroids exhibiting the 18a-methyl group. This new steroid is an estrone derivative.