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Allylic Oxidation: Easy Synthesis of Alkenones from Activated Alkenes with TEMPO.

✍ Scribed by Tony Breton; Denis Liaigre; El Mustapha Belgsir


Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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Ξ±-Hydroxyacids can be enantioselectively prepared by means of a two-step oxidation process, involving first the asymmetric dihydroxylation of a terminal alkene and subsequent oxidation with TEMPO/NaOCl/NaClO 2 in good to excellent yields. No fragmentation of the glycol intermediate was detected.

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