Ξ±-Hydroxyacids can be enantioselectively prepared by means of a two-step oxidation process, involving first the asymmetric dihydroxylation of a terminal alkene and subsequent oxidation with TEMPO/NaOCl/NaClO 2 in good to excellent yields. No fragmentation of the glycol intermediate was detected.
β¦ LIBER β¦
Allylic Oxidation: Easy Synthesis of Alkenones from Activated Alkenes with TEMPO.
β Scribed by Tony Breton; Denis Liaigre; El Mustapha Belgsir
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 17 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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