Allosteric transition of erythrocyte alkaline phosphatase from duchenne muscular dystrophy (DMD) patients and duchenne muscular dystrophy carriers (Homo sapiens)

Multiexon skipping leading to an artific

Multiexon skipping leading to an artificial DMD protein lacking amino acids from exons 45 through 55 could rescue up to 63% of patients with Duchenne muscular dystrophy

✍ Christophe Béroud; Sylvie Tuffery-Giraud; Masafumi Matsuo; Dalil Hamroun; Véroni 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 292 KB

## Communicated by Haig H. Kazazian Approximately two-thirds of Duchenne muscular dystrophy (DMD) patients show intragenic deletions ranging from one to several exons of the DMD gene and leading to a premature stop codon. Other deletions that maintain the translational reading frame of the gene re