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Allosteric properties of hemoglobin and the plasma membrane of the erythrocyte: New insights in gas transport and metabolic modulation

✍ Scribed by Maria Cristina De Rosa; Cristiana Carelli Alinovi; Antonio Galtieri; Annamaria Russo; Bruno Giardina

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 200 KB
Volume: 60
Category: Article
ISSN: 1521-6543
DOI: 10.1002/iub.15

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✦ Synopsis

Abstract

Within the red blood cell the hemoglobin molecule is subjected to modulation mechanisms, namely homo‐ and heterotropic interactions, which optimize its functional behavior to the specific physiological requirements. At the cellular level, these modulation mechanisms are utilized to perform a number of other functions that are not minor with respect to the basic function of oxygen transport. Here we report some key examples concerning: (i) the interaction of hemoglobin with band 3 and its influence on glucose metabolism; (ii) the role of the ligand‐linked quaternary transition of hemoglobin in the control of “NO bioactivity” and of gas diffusion; (iii) the interaction of plasma membrane with the various oxidative derivatives of the hemoglobin molecule. © 2008 IUBMB IUBMB Life, 60(2): 87–93, 2008

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