Allosteric effect of gallamine on muscarinic cholinergic receptor binding
โ Scribed by Tanjore K. Narayanan; Robert S. Aronstam
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 491 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0364-3190
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๐ SIMILAR VOLUMES
The classical (acetylcholine) binding sites of all five subtypes of muscarinic receptors are known to be subject to allosteric regulation by a variety of small molecules. The hallmarks of such modulation in binding assays are that the allosteric ligands can alter both the affinities and the rates of
Addition of lithium in vitro inhibited the binding of [3H]( -)QNB to muscarinic cholinergic receptors of homogenates of tissue prepared from the striatum, cortex, and hippocampus of rat brain. Chronic in vivo exposure of rats to lithium in their food produced serum levels of lithium comparable to th