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Allosteric and binding properties of Asp1–Glu382 truncated recombinant human serum albumin – an optical and NMR spectroscopic investigation

✍ Scribed by Gabriella Fanali; Giorgio Pariani; Paolo Ascenzi; Mauro Fasano


Book ID
111312884
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
339 KB
Volume
276
Category
Article
ISSN
1432-1327

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The binding of racemic, (R)([) and (S)(])-ibuprofen (IBP) to human serum albumin (HSA) was studied using NMR spectroscopy. Having saturated the tight binding sites, the extent of weak binding was then investigated. The molecular di †usion coefficients of IBP in HSA solution at di †erent concentratio