✦ LIBER ✦

Allopurinol-induced melanism in the tiger salamander (Ambystoma tigrinum nebulosum)

✍ Scribed by Frost, Sally K. ;Bagnara, Joseph T.

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 874 KB
Volume: 209
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402090311

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The enzyme, xanthine dehydrogenase (XDH), has been examined in Ambystoma tigrinum nebulosum with respect to its role in pigmentation. It now seems probable that the melanoid gene (m) either codes directly for XDH or is somehow intimately connected with the normal function of this enzyme. Inhibition of XDH using the drug, allopurinol, results in animals which appear to be phenocopies of melanoid mutants as described for the Mexican axolotl (Ambystoma mexicanum). The effects of allopurinol in terms of specific pigmentary alterations were examined, and a new method for analyzing heterogeneous extracts of skin pigments (e.g., purines and pteridines) is presented. The significance of the link between XDH and melanism is discussed with emphasis on possible mechanisms of pigment induction and general applicability to biological systems.

📜 SIMILAR VOLUMES

Morphology of physiologically identified

Morphology of physiologically identified bipolar cells in the retina of the tiger salamander, Ambystoma tigrinum

✍ William Alan Hare; Janet S. Lowe; Geoffrey Owen 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

The relationship of acetylcholinesterase

The relationship of acetylcholinesterase activity to optic fiber projections in the tiger salamander Ambystoma tigrinum

✍ Edward R. Gruberg; Gerald A. Greenhouse 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 931 KB

## Abstract In the tiger salamnder the distribution of optic fibers, as revealed by the Fink‐Heimer method, is compared with the localization of acetylcholinesterase, as revealed by histochemical methods. AChE activity coincides with optic nerve axons in the optic fiber layer of the retina, in the

Experimental analysis of character coupl

Experimental analysis of character coupling across a complex life cycle: Pigment pattern metamorphosis in the tiger salamander, Ambystoma tigrinum tigrinum

✍ David M. Parichy 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 289 KB

Developmental relationships among characters are expected to bias patterns of morphological variation at the population level. Studies of character development thus can provide insights into processes of adaptation and the evolutionary diversification of morphologies. Here I use experimental manipul

Effects of hypoxia on acid-base balance,

Effects of hypoxia on acid-base balance, blood gases, catecholamines, and cutaneous ion exchange in the larval tiger salamander (Ambystoma tigrinum)

✍ Talbot, Colleen R. ;Stiffler, Daniel F. 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 759 KB

## Abstract The effects of hypoxia on acid‐base balance and blood gases were examined in larval __Ambystoma tigrinum__. Environmental hypoxia (P = 24 mm Hg) resulted in a severe metabolic acidosis. During approximately 4 hr of hypoxia, arterial P fell from 23 to 8 mm Hg while P did not change; plas